Balanced Calcium and Magnesium
Calcium and Magnesium in Optimum Natural Balance
| $8.99 | 60 Count Bottle VP4050A | Retails for $9.90 | |
| $89.99 | 90 Count Bottle VPD4050A | Retail Value for $118.80 | |
| $11.99 | 90 Count Bottle VP4050P | Retails for $13.90 | |
| $119.99 | 12 Bottles 90 Count Each | Retail Value 166.80 | |
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Display An Attractive 12 Bottle Case On Your Counter for Patient/Client Convenience. Additional Wholesale Discounts Available |
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No Sugar, Salt, Starch, Preservatives or Artificial Colorings Added
Two tablets supply 100% of the U.S. RDA for each of these minerals.
| Each 2 Tablets Contain | Potency | RDA |
| Calcium (Calcium Carbonate) | 1,000 mg | 100% |
| Magnesium (Magnesium Oxide and Magnesium Gluconate) |
400 mg | 100% |
Calcium May Only Protect Against Colorectal Cancer In Presence Of Proper Levels Of Magnesium
High magnesium intake has been associated with low risk of colorectal cancer. Americans have similar average magnesium intake as East Asian population however, the United States has seen a much higher colorectal cancer incidence rate than East Asian populations.
Furthermore, when East Asians immigrated to the United States, their incidence rates for colorectal cancer increased.
This led researchers at Vanderbilt University to suspect there was some other factor to consider.
Calcium supplementation has been shown to inhibit colorectal carcinogenesis although high calcium may simultaneously be preventing the body from absorbing magnesium. Unfortunately, although patients in United States have a higher calcium intake, they experience a higher colorectal cancer incidence.
Researchers at Vanderbilt University believe if only calcium levels were involved, one can expect the opposite direction. They believe there may be something about these two factors magnesium and calcium combined, essentially the ratio of one of these essential minerals to the other.
The research team examined this hypothesis in a large clinical trial and found that supplementation of calcium only reduced the risk of adenoma recurrence if the ratio of calcium to magnesium was low and remained low during treatment. The risk of colorectal cancer adenoma recurrence was reduced by 32 percent among those with baseline calcium to magnesium ratio below the median in comparison to no reduction for those above the median levels.
The implications for prevention of adenoma recurrence or reduced risk of primary colorectal cancer is that developing a proper diet and nutritional supplementation regimen that takes the ratio of both essential calcium and magnesium into account may be better than supplementing with one or the other mineral alone.
About one in eighteen individuals will develop colorectal cancer in their lifetime and 40 percent will die within five years of diagnosis, mainly due to diagnosis at a late stage. The understanding of how dietary factors affect colorectal cancer may lead to the prevention of cancer recurrence and possibly prevention of the initial cancer.
American Association for Cancer Research (2008, November 18).
Of the approximately 1,000 g of calcium in the average 70 kg adult body, almost 98% is found in bone, 1% in teeth, and the rest is found in blood, extracellular fluids, and within cells where it is a co-factor for a number of enzymes. Calcium promotes blood clotting by activating the protein fibrin, and along with magnesium helps to regulate the heart beat, muscle tone, muscle contraction and nerve conduction.
There are about 19 g of Mg in the average 70 kg adult body, of which approximately 65% is found in bone and teeth, and the rest is distributed between the blood, body fluids, organs and other tissue.
Find Calcium and Magnesium Supplements at a Featured Merchant (below)
Magnesium is involved in the synthesis of protein, and it is an important co-factor in more than 300 enzymatic reactions in the human body, many of which contribute to the production of energy, and with cardiovascular functions. While calcium affects muscle contractions, magnesium balances that effect and relaxes muscles. Most of magnesium is inside the cell, and while iron is the central atom in hemoglobin, magnesium is the central core of the chlorophyll molecule in plant tissue.
Magnesium May Benefit Blood Pressure in Hypertensives
New Study From Korea Recommends This Essential Mineral For Cardiovascular Health.
Supplemental Magnesium may reduce blood pressure in people with elevated blood pressure, as published in Nutrition, Metabolism and Cardiovascular Diseases.
These findings suggest that Magnesium supplementation may help prevent the progression of hypertension in normo-magnesemic non-diabetic overweight people with higher Blood Pressure, although mechanisms of counter-regulation preventing further Blood Pressure increase remain to be studied further, concluded the researchers from Pusan National University.
The study adds to findings from epidemiological studies which reported that more Magnesium, Potassium and Calcium may reduce the risk of hypertension in certain populations.
High blood pressure (hypertension), defined as having a systolic and diastolic blood pressure (BP) greater than 140 and 90 mmHg, is a major risk factor for cardiovascular disease (CVD).
Since very little is known about how Magnesium may effect insulin sensitivity and blood pressure in healthy individuals, the researchers recruited 155 people to take part in a double-blinded, placebo-controlled, randomised trial. The subjects, who had an average BMI of 23 kg/m2, were randomly assigned to receive either daily supplements of 300 mg of elemental Magnesium in the Magnesium oxide form or placebo for 12 weeks.
At the end of the study, no significant differences were observed between the Magnesium or placebo groups. However, when the researchers looked specifically at hypertensives, significant decreases in both systolic and diastolic blood pressure were observed in the Magnesium group (17.1 and 3.4 mmHg, respectively), compared to placebo (6.7 and 0.8 mmHg, respectively).
Most of epidemiologic studies have shown an inverse association between Magnesium intake and fasting insulin concentration or the incidence of type 2 diabetes although associations for Magnesium-rich diets in these studies may reflect other beneficial dietary components such as fibers in foods that are high in magnesium. Thus, Magnesium supplements could be an alternative tool for the prevention of type-2 diabetes and metabolic syndrome.
Magnesium and Diabetes
A meta-analysis of prospective cohort studies by researchers at Stockholm's Karolinska Institutet, reported that for every 100 milligram increase in Magnesium intake, the risk of developing type-2 diabetes decreased by 15 per cent.
An article in The Journal of Internal Medicine concluded that while it is too early to recommend magnesium supplements for type-2 diabetes prevention, increased consumption of Magnesium-rich food seems prudent.
Source: Nutrition, Metabolism and Cardiovascular Diseases "Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults" Authors: S. Lee, H.K. Park, S.P. Son, C.W. Lee, I.J. Kim, H.J. Kim
High Blood Pressure Linked To Memory Problems In Middle Ages
High blood pressure is linked to memory problems in people over 45, according to research published in the August 25, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
The study found that people with high diastolic blood pressure, which is the bottom number of a blood pressure reading, were more likely to have cognitive impairment, or problems with their memory and thinking skills, than people with normal diastolic readings.
For every 10 point increase in the reading, the odds of a person having cognitive problems was seven percent higher. The results were valid after adjusting for other factors that could affect cognitive abilities, such as age, smoking status, exercise level, education, diabetes or high cholesterol.
The study involved nearly 20,000 people age 45 and older across the country who participated in the Reasons for Geographic And Racial Differences in Stroke (REGARDS) Study and had never had a stroke or mini-stroke. A total of 1,505 of the participants, or 7.6 percent, had cognitive problems, and 9,844, or 49.6 percent, were taking medication for high blood pressure. High blood pressure is defined as a reading equal to or higher than 140/90 or taking medication for high blood pressure.
"It's possible that by preventing or treating high blood pressure, we could potentially prevent cognitive impairment, which can be a precursor to dementia," explained a research team from the University of Alabama at Birmingham, including members of the American Academy of Neurology.
Research has shown that high diastolic blood pressure leads to weakening of small arteries in the brain, which can result in the development of small areas of brain damage. They explained more research is needed to confirm the relationship between high blood pressure and cognitive impairment.
The study was supported by the National Institute of Neurological Disorders and Stroke (NINDS). The REGARDS study is one of the largest population-based studies of risk factors for stroke. These latest data suggest that higher blood pressure may be a risk factor for cognitive decline, but further studies will be necessary to understand the cause-effect relationship,
The deputy director of the American Academy of Neurology noted "The National Institutes of Health is now organizing a large clinical trial to evaluate whether aggressive blood pressure lowering can decrease a number of important health outcomes including cognitive decline."
Adapted from materials provided by American Academy of Neurology.
