Glucosamine Plus
Anti-Inflamatory Herbal Blend with Boswellia Extract, Curcuminoids
| $14.95 | 60 Count Bottle VP1137A | Retails for $18.90 | |
| $64.95 | 5 Bottles 60 Count Each | Retail Value $94.50 | |
| $149.99 | 12 Bottles 60 Count Each | Retail Value $226.80 | |
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Display An Attractive 12 Bottle Case On Your Counter for Patient/Client Convenience. Additional Wholesale Discounts Available |
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Optimum Cartilage Nutrition For Healthy Joints
Glucosamine Plus, the dietary supplement providing cartilage nutrition for healthy joints, contains pharmaceutical-grade Glucosamine HCl plus synergistic anti-inflammatory natural herbal complex. Glucosamine hydrochloride is the form most highly regarded by nutrition experts as the best source of Glucosamine for human nutrition.
Glucosamine Plus is The Specially-Formulated Dietary Supplement Supplying Glucosamine HCl Plus Synergistic Curcuminoid-Boswellia (Tumeric Complex) Valued For Their Anti-inflammatory Effects.
Turmeric Ingredient-Curcumin Affects Membranes At The Cellular Level, For Better Health…
Revered in India as "holy powder," the marigold-colored spice known as turmeric has been used for centuries to treat wounds, infections and other health problems. In recent years, research into the healing powers of turmeric's main ingredient, Curcumin, has increased, as its impressive array of antioxidant, anti-cancer, antibiotic, anti-inflammatory anti-viral and other properties has been revealed.
Researchers have discovered Curcumin acts as a cellular disciplinarian, inserting itself into cell membranes and making them more orderly, which helps improve cells' resistance to infection, inflammation and malignancy. Curcumin regulates the action of membrane proteins indirectly, by changing the physical properties of the membrane.
The effects of Curcumin on the formation of amyloids (clumps of fibrous protein) believed to be involved in type 2 Diabetes, Alzheimer's disease, Parkinson's disease, and many other maladies. Researchers are looking to determine if other natural substances, such as Polyphenols (compounds found in many plant foods that are known to have antioxidant properties) and Capsaicin (a pain reliever derived from hot peppers) also interact favorably with membranes in the same way as Curcumin and Boswellia.
No Sugar, Starch, Salt. No Artificial Colorings, Flavorings or Preservatives.
| Each 2 Tablets Contain | |
| Glucosamine (as glucosamine HCI) |
700 mg |
| Boswellia extract (Boswelia thurifera) (essential oil) |
200 mg |
| Curcuminoids (Curcuma longa)(rhizome) |
200 mg |
| Uva Ursi standardized extract (20% arbutin) (Arctostaphylos uva-ursi) (leaf) | 20 mg |
| Proprietary herbal blend Buchu (Barosma betulin)(leaf), Dandelion (Taraxacum vulgare)( root), Corn silk (Zea mays)(stylus), Juniper berry (Juniperuscommunis)(fruit) |
15 mg |
The Nutritional-Science of Glucosamine and How It Works In the Human Body
Arthritis is defined as the cartilage proteoglycan degradation of the gelatinous connective tissue (containing collagen and proteoglycan) which covers the ends of bones for nourishing and lubricating the joints required to maintain the elasticity needed for normal movement and shock absorption. This breakdown of tissue causes extreme pain and can often be incapacitating. Unfortunately, this condition affects millions of people.
The rationales of prescribing NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) in the treatment of osteoarthritis are controversial. Recent news about the harmful side-effects of these drugs is a major cause for concern from people suffering with this condition.
For many years Glucosamine has successfully demonstrated natural and safe healing abilities. The pharmacological therapeutic index of Glucosamine with regard to anti-inflammatory activity seems superior to NSAIDs. The results of clinical data show that either Glucosamine hydrochloride or Glucosamine Sulphate supplementation will lead to long lasting pain reduction and functional improvement by means of increasing anabolic mechanisms by reducing the activity of proteolytic enzymes with its anti-inflammatory effects.
Most importantly, treatment with Glucosamine is not accompanied by the known unwanted side effects (i.e - nausea, gastric irritation, anorexia, cardiovascular ailments, etc.) and is very well tolerated by patients of all ages with both short and long term use.
Find Glucosamine Anti Inflammatory Supplements at a Featured Merchant (below)
It is suggested that Glucosamine should be considered as a basic therapy for the management of degenerative osteoarthritis disorders because of the following key factors:
TISSUE DISTRIBUTION: Glucosamine is a naturally-occurring aminosaccharide, naturally synthesized from glucose in the human body. It is easily absorbable and measurements show blood levels are consistently diffused rapidly in all tissues.
EFFECTS ON CHONDROCYTES AND FIBROBLASTS: Glucosamine stimulates these cells to increase their anabolism, causing increased synthesis of glycosaminoglycans that are building blocks of proteoglycans. It has also been reported that Glucosamine stimulates synovial production of hyaluronic acid, which is primarily responsible for the lubricating and shock absorbing properties.
ANTI-INFLAMMATORY PROPERTIES: Glucosamine is able to inhibit in vitro superoxide generation and lysosomal enzymes of the liver; The effective anti-inflammatory actions and the relative safety of Glucosamine supplementation make it particularly valuable for the treatment of arthritis and rejuvenation of cartilage.
TOXIC EFFECTS: Glucosamine is almost devoid of toxicity and is suitable for long-term therapeutic use.
CARTILAGE REJUVENATION MECHANISM: After oral ingestion, Glucosamine (sulphate or hydrochloride) is readily absorbable by the gastrointestinal tract as neutral amines are diffusable throughout the body by the blood stream. The free Glucosamine is transported into chondrocytes of the cartilage and is converted into glycosaminoglycans (GAG), which are the building blocks of proteoglycans, that are the key constituents of the cartilage.
Glucosamine helps in stimulating the anabolic metabolism of cartilage, inhibiting joint degradation and prostaglandin production. Glucosamine is required for the synthesis of hyaluronic acid, a compound known to play a critical role in wound healing. Glucosamine has the ability to alleviate pain, and enhance joint flexibility without any side effects.
GLUCOSAMINE: Healthy joints ordinarily make their own Glucosamine. It’s the basic building block the body uses to make cartilage. But as we grow older or injure a joint, we often don’t produce enough Glucosamine. Less Glucosamine means less cartilage. A dietary supplement of Glucosamine helps maintain joint flexibility, prevents joint degeneration, and helps the body produce new cartilage . . . all without any side effects.
BOSWELLIA: An herb from the Indian Ayurvedic tradition, improves blood supply to the joints and prevents tissue deterioration. Boswellia is valuable because, although it acts like a NSAID, it does not produce the side effects of pharmaceutical NSAIDs. One clinical trial of 175 rheumatoid arthritis patients found that Boswellic supplements, improved grip strength, morning pain and stiffness, and physical performance in 97 percent of patients after three to four weeks of treatment.
CURCUMINOIDS: Today, curcumin – an extract from the turmeric spice – is gaining worldwide recognition for its potent ability to quell inflammation. (As one of the oldest anti-inflammatory drugs used by traditional Indian medicine, turmeric is not actually a new discovery.) Animal studies, as well as some preliminary work with people, show very promising results, without negative side effects.
Curcumin and Other Natural Ingredients from Turmeric Regulate Membranes For Better Health
Revered in India as "holy powder," the marigold-colored spice known as turmeric has been used for centuries to treat wounds, infections and other common health problems.
In recent years, research into the healing powers of turmeric's ingredients- curcumin and boswelia have increased significantly, as an impressive array of health-building antioxidant, anti-cancer, antibiotic, antiviral and other properties has been revealed.
Up until now, little has been known about exactly how curcumin works inside the body. Recently, University of Michigan researchers have discovered that curcumin acts as a disciplinarian, inserting itself into cell membranes and making them more orderly, a function that improves cells' resistance to infection and malignancy. The findings were published in the Journal of the American Chemical Society.
Scientists have speculated that curcumin does its health-promoting work by interacting directly with membrane proteins, but the new research findings challenge that notion. Instead, the researchers found that curcumin regulates the action of membrane proteins indirectly, by actually changing the physical properties of the membrane.
In a related line of research, the team is using the same methods to investigate the effects of curcumin on the formation of amyloids---clumps of fibrous protein believed to be involved in type 2 diabetes, Alzheimer's disease, Parkinson's disease, and many other maladies. In addition, the researchers are now looking to see whether other natural compounds, such as polyphenols (found in many plant foods that are known to have antioxidant properties) and capsaicin (a pain reliever derived from hot peppers), interact with membranes in the same way as curcumin.
This research was supported by funding from the National Institutes of Health.
Adapted from materials provided by University of Michigan
Curcumin Is Now Studied For It's Immune-Boosting Power
The health boosting activity of Curcumin may be due to the molecule's ability to stabilize cell membranes and increase the cell's resistance to infection, suggests an important new study.
The research, published in the prestigious Journal of the American Chemical Society, may help scientists understand how Curcumin works inside the body.
Researchers at the University of Michigan used solid-state NMR spectroscopy to show that Curcumin physically alters the cell membrane at an atomic level.
Curcumin, the natural pigment that gives the spice turmeric its yellow colour, has increasingly come under the scientific spotlight in recent years for its many health benefits. Recent studies have been investigating its potential value for reducing cholesterol levels, improving cardiovascular health, reducing the risk of Alzheimer's, and potential protection against cancer.
Turmeric has a long history of use in ancient medicine for the treatment of wounds, infections, and other health problems.
Nutrition experts recommend however that consumers wishing to make use of curcumin's properties consume it in supplement form rather than eating more curries, which tend to be high in fat.
According to the researchers, Curcumin can induce a negative curvature of the membrane, which would explain the potential anti-cancer activity of the compound, since other studies have shown that such changes may increase the activity of specific proteins, which play an important role in apoptosis, or programmed cell death.
Using solid-state NMR spectroscopy, the research team report that molecules of Curcumin insert themselves into cell membranes and make the membranes more stable and orderly. This makes the cells more resistant to infection by disease-causing microbes, they added. The study also revealed that Curcumin exerts this strong effect on the membrane structure at low concentrations.
Recently, Curcumin has been studied and linked to a wide range of health benefits, including:
- Potential Protection Against Prostate Cancer (Clinical Cancer Research, 2008:14 ), Alzheimer's (Journal of Alzheimer's Disease, 2006, Vol. 10, pp. 1-7; American Journal of Epidemiology, 2006, Vol. 164, pp. 898-906),
- Protection Against Heart Failure (Journal of Clinical Investigation, doi: 10.1172/JCI32865);
- Protection Against Diabetes (Molecular Nutrition & Food Research, 2008, doi: 10.1002/mnfr.200700184);
- Protection Against Arthritis (Arthritis & Rheumatism, 2006, Vol. 54, pp. 3452-3464).
Curcumin May Help Cut Body Fat and Weight Gain, According To New Laboratory Study
Curcumin, the natural turmeric spice, may reduce body weight gain, and help in the fight against obesity, suggests new data from a controlled laboratory study.
Laboratory subjects fed a high-fat diet and supplemented with Curcumin were found to have reduced body weight gain, as well as lowering blood cholesterol levels, according to findings published in the Journal of Nutrition.
The Curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism may contribute to lower body fat and body weight gain explained researchers from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
Dietary curcumin may have a potential benefit in preventing obesity. With 50 per cent of Europeans and 62 per cent of Americans classed as overweight, the food industry is focussing on the potential of products for weight loss and management.
Nutrient-based weight-control and slimming products are based on the mechanisms of action, including:
- Boosting fat burning - thermogenesis
- Inhibiting protein breakdown
- Suppressing appetite and boosting satiety (feeling of fullness)
- Blocking fat absorption
The researchers performed in vitro and in vivo experiments. The effects of different doses of Curcumin on the growth (differentiation) of 3T3-L1 fat cells (adipocytes) showed a suppression of differentiation and an increase in programmed cell death (apoptosis).
The in vivo experiments involved feeding laboratory mice a high-fat diet (22 per cent) and supplementing with Curcumin in the diet for 12 weeks. The ingredient was found to reduce body weight gain and fat mass, without affecting the levels of food intake, wrote the researchers.
Furthermore, a reduction was noted in the expression of vascular endothelial growth factor (VEGF), one of a number of genes associated with angiogenesis (blood vessel formation that is necessary for the growth of fat tissue).
Curcumin was also associated with significantly lower cholesterol levels and a reduction in the expression of peroxisome proliferators-activated receptor gamma (PPAR-gamma), a protein that plays a role in metabolic functions.
Source: Journal of Nutrition
Curcumin Could Reduce Breast Cancer Risk In Women Exposed To Hormone Replacement Therapy
Previous studies have found that postmenopausal women who have taken a combined estrogen and progestin hormone replacement therapy have increased their risk of developing progestin-accelerated breast tumors. Now, University of Missouri researchers have found that curcumin, a popular Indian spice derived from the turmeric root, could reduce the cancer risk for women after exposure to hormone replacement therapy.
Approximately 6 million women in the United States use hormone replacement therapy to treat the symptoms of menopause; This exposure to progestin will predispose a large number of post-menopausal women to future development of breast cancer. The results of a new study show that women could potentially take curcumin to protect themselves from developing progestin-accelerated tumors.
In the study, researchers found that curcumin delayed the first appearance, decreased incidence and reduced multiplicity of progestin-accelerated tumors in an animal model. Curcumin also prevented the appearance of gross morphological abnormalities in the mammary glands. In previous studies, University of Missouri researchers showed that progestin accelerated the development of certain tumors by increasing production of a molecule called VEGF that helps supply blood to the tumor. By blocking the production of VEGF, researchers could potentially reduce the proliferation of breast cancer cells. Curcumin inhibits progestin-induced VEGF secretion from breast cancer cells.
The team noted "Curcumin and other potential anti-angiogenic compounds should be tested further as dietary chemopreventive agents in women already exposed to hormone replacement therapy containing estrogen and progestin in an effort to decrease or delay the risk of breast cancer associated with combined hormone replacement therapy."
Journal reference: Curcumin delays development of MPA-accelerated DMBA-induced mammary tumors. Menopause, (in press) University of Missouri-Columbia.
