Vitamins A and D Softgel Capsules
Essential A and D Vitamins From Halibut Liver Oil
| $4.99 | 100 Count Bottle VP200R | Retails for $5.90 | |
| $10.49 | 250 Count Bottle VP200U | Retails for $13.90 | |
| $104.99 | 12 Bottles 250 Count Each | Retail Value $166.80 | |
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Display An Attractive 12 Bottle Case On Your Counter for Patient/Client Convenience. Additional Wholesale Discounts Available |
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This balanced combination provides 5000 i.u. of Vitamin A and 400 i.u. of Vitamin D (100% of the Daily Value for each). The vitamin activity in this formulation is supplied by Halibut Liver Oil in easy-to-swallow soft gelatin capsules.
Formulated without caffeine, corn, gluten, milk or egg deritives sodium, soy, sugar, starch, wheat or yeast. No preservatives, flavorings or artificial coloring added.
Find Vitamin A and D Supplements at a Featured Merchant (below)
Older Americans have a higher risk of developing vitamin D deficiency. The ability of skin to convert vitamin D to its active form decreases as we age. The kidneys, which help convert vitamin D to its active form, sometimes do not work as well when people age. Therefore, some older Americans may need vitamin D from a supplement.
It is important for individuals with limited sun exposure to include good sources of vitamin D in their diets. Homebound individuals, people living in northern latitudes such as in New England and Alaska, women who cover their body for religious reasons, and individuals working in occupations that prevent exposure to sunlight are at risk of a vitamin D deficiency. If these individuals are unable to meet their daily dietary need for vitamin D, they may need a supplement of vitamin D.
Vitamin D Can Alter Colon Cancer Cells In Many Ways
Vitamin D has the ability to moderate the rogue colon cancer cell by adjusting everything from its gene structure to its cytoskeleton.
In the November 17 issue of the Journal of Cell Biology, a research team shows that one pathway governs the vitamin D's diverse effects. The results help clarify the actions of a molecule that is undergoing clinical trials as a cancer therapy.
Vitamin D hinders colon cancer cells in two ways... It switches on genes such as the one that encodes E-cadherin, a component of the adherens junctions that anchor cells in epithelial layers. The vitamin also induces effects on the cytoskeleton that are required for gene regulation and short-circuiting the key pathway which is overactive in most colon tumors. The net result is to curb division and incite colon cancer cells to differentiate into epithelial cells that subside instead of spreading.
To investigate the mechanism, the team dosed colon cancer cells with metabolically active version of vitamin D (Calcitriol) triggered a surge of calcium into the cells which then awakened two other kinases. Each step in this nongenomic pathway was necessary to spur the genomic responses, the researchers showed. The team also focused on the contribution of the vitamin D receptor (VDR). The receptor was crucial at the beginning of the pathway, where it permitted the calcium influx, and at the end, where it activated and repressed genes.
The study is the first to show that vitamin D's genomic and nongenomic effects integrate to regulate cell physiology. The researchers now want to determine whether receptor from different locations (including the cell nucleus and the cell membrane) has different functions in the pathway.
Vitamin D Supplements Associated With Reduced Fracture Risk In Older Adults
Oral vitamin D supplements at a dose of at least 400 international units per day are associated with a reduced risk of bone fractures in older adults, according to results of an important new study and follow up analysis.
The benefits of vitamin D for helping reduce bone fractures have been questioned by several recent trials, leading to uncertainty among patients and physicians regarding recommendations for vitamin D supplementation.
Factors that may obscure a benefit of vitamin D are low adherence to treatment, improper dose of vitamin D or the use of low potency sources.
Researchers at the University of Zurich, University Hospital, Zurich, Switzerland performed a meta-analysis on 12 previously published clinical trials of oral vitamin D supplements among adults age 65 or older. These double-blind randomized controlled trials involved 42,279 participants (average age 78) and examined non-vertebral (non-spinal) fractures, including eight trials of 40,886 participants specifically studying hip fractures.
When the results of the trials were studied, Vitamin D supplements decreased the risk of non-vertebral fractures by 14 percent and of hip fractures by 9 percent. The authors then pooled the results of only the nine trials in which participants received doses of more than 400 international units per day. At this dosage, vitamin D supplements reduced non-vertebral fractures by 20 percent and hip fractures by 18 percent. Doses of 400 international units per day or lower did not reduce the risk of either fracture type. A greater reduction in risk was also seen among trial participants whose blood levels of 25-hydroxyvitamin D (a commonly used measure of blood vitamin D levels) achieved a greater increase.
Among individuals taking high doses of vitamin D, additional calcium did not appear to have any further protective effect against fractures. However, the improved calcium-efficiency and optimized utilization effect of vitamin D may explain why the researchers did not see an added benefit of calcium supplementation at a higher dose of vitamin D.
The greater fracture reduction with a higher received dose or higher achieved 25-hydroxyvitamin D levels for both any non-vertebral fractures and hip fractures suggests that higher doses of vitamin D should be explored in future research to maximize anti-fracture efficacy. It is also possible that greater benefits may be achieved with earlier initiation of vitamin D supplementation and longer duration of consistent use.
This study was supported by a Swiss National Foundation Professorship grant and a fellowship grant by the Robert Bosch Foundation.
Journal reference: Bischoff-Ferrari et al. Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-analysis of Randomized Controlled Trials. Archives of Internal Medicine, 2009
